منابع مشابه
Neurotoxicity of general anesthetics: cause for concern?
GENERAL anesthetics are highly lipid soluble and can dissolve in every membrane, penetrate into organelles, and interact with numerous cellular constituents. Their actions have long been considered rapid and fully reversible, with the pharmacodynamic time course of anesthesia dictated solely by the pharmacokinetic profiles of anesthetic uptake and elimination. But recent laboratory data call fo...
متن کاملNeurotoxicity of general anesthetics: anesthesia and Alzheimer's disease in Serbia.
A large body of preclinical as well as some retrospective clinical evidence suggest that exposure to general anesthesia could be detrimental to cognitive development in young subjects, and might also contribute to accelerated cognitive decline in the elderly. Though general anesthetics have now been used clinically for well over a century, both their mechanisms of action as well as the nature o...
متن کاملDual effects of neuroprotection and neurotoxicity by general anesthetics: role of intracellular calcium homeostasis.
Although general anesthetics have long been considered neuroprotective, there are growing concerns about neurotoxicity. Preclinical studies clearly demonstrated that commonly used general anesthetics are both neuroprotective and neurotoxic, with unclear mechanisms. Recent studies suggest that differential activation of inositol 1,4,5-trisphosphate receptors, a calcium release channel located on...
متن کاملMechanisms of action of general anesthetics.
Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive procedures. However, the underlying neurocellular mechanisms by which the state of general anesthesia is achieved are only just beginning to be ...
متن کاملGeneral anesthetics and molecular mechanisms of unconsciousness.
The term ‘‘anesthesia’’ was originally used by the ancient Greek surgeon Dioscorides and resurrected by Dr Oliver Wendell Holmes to describe the insensible state produced by inhalation of ether. The goals of general anesthesia include amnesia, unconsciousness (also termed hypnosis), and immobilization. By definition, general anesthetics reversibly produce all 3 of these therapeutic effects. Gen...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2009
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181bf1d61